Summary of the gene
The Structure, Biosynthesis and function of the tRNA Trp gene
The tRNA gene was discovered nearly five decades ago. It is a gene that is three-dimensional in nature. Synthesis of the gene for tRNA and the synthetic gene for an amber suppressor tRNA is functionalin vivo ( Soll & RajBhandary, 1995).. Sequence information of tRNAs and tRNA genes indicate the following: (i) the genetic code in mitochondria as well as in some organisms often vary in some ways from their universal genetic code, (ii) Mitochondria and organisms having high compacted genomes utilize a codon reading sequence that varies from that of most organisms besides requiring lessef amounts of tRNAs to read all the codons of the genetic code, (iii) tRNA gene transcripts could undergo editing in some cases. Modified nucleotides play a role in creating specificity in aminiacylation of a tRNA and others influence the codon reading properties or the translation activities associated with the tRNA gene ( Soll & RajBhandary, 1995)..
General functions of the tRNA Trp gene
It is a gene whose main function is in the transfer of RNAs. However, it pertakes a multitude of functions which include: Amino acid biosynthesis, biosynthesis of cofactors, prosthetic groups, and carriers, cell envelope, Cellular processes, Central intermediary metabolism. It also features in the photosynthesis and respiration; purines, pyrimidines, nucleodides, and nucleotides; Regulatory functions; DNA replication, recombination, and repair; Transcription, and Translation. Futhermore, the tRNA: Trp gene is key in transport and binding proteins; Energy metabolism; Fatty acid, together wit phospholipid and sterol metabolism. Therefore, the tRNA gene has specialized functions in protein synthesis and cellular metabolism ( Soll & RajBhandary, 1995).
Reference:
Soll, Dieter, & RajBhandary. (1995). tRNA: structure, biosynthesis, and function. United States, ASM Press.
