Epigenetic influence on immunity

Title:Epigenetic influence on immunity

Work:Describe epigenetic mechanisms involved in the regulation of gene expression with reference to their influence in the immune system

You should use tables and diagrams as appropriate. Your assignment must be fully referenced and include a bibliography. Max 1500 words (not including references) – please include the word count for your assignment on the first page. Include your student ID in the header of each page. Each page should be numbered as pg X of Y.

Suggested resources:
– Hirst M & Marra MA (2009) Epigenetics and human disease. Int J Biochem & Cell Biol 41:136-146

– Backdahl L, Bushell, A & Beck S (2009) Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int J Biochem & Cell Biol 41:176-184

– Editorial (March 2013) The dynamic epigenome. Nature Structural and Molecular Biology. 20:258 (Focus issue)

– Teperino R, Lempradl A & Pospisilik JA (2013) Bridging epigenomics and complex disease: the basics. Cell Mol Life Sci 70:1609-1621

– Mercer TR & Mattick JS (2013) Structure and function of long non-coding RNAs in epigenetic regulation. Nat Struct and Mol Biol. 20:300-306

– Kanno Y et al (2012) Transcriptional and epigenetic control of T helper cell specification: Molecular mechanisms underlying commitment and plasticity. Ann Rev Immunol 30:707-731

– Wilson CB, Rowell E & Sekimata M (2009) Epigenetic control of T-helper-cell differentiation. Nat Rev Immunology 9:91-104

– Naito T & Taniuchi (2013) Roles of repressive epigenetic machinery in lineage decision of T cells. Immunology 139:151-157

– Ohkura N, Kitagawa Y & Sakaguchi S (2013) Development and maintenance of regulatory T cells. Immunity 38:414-423

– Richardson B (2007) Primer: epigenetics of autoimmunity. Nature Clinical Practice RHEUMATOLOGY 3: 521-527

– Brooks WH et al (2010) Epigenetics and autoimmunity. J Autoimmunity 34:J207-J219

-Bierne H, Hampn M and Cossart P (2012) Epigenetics and bacterial infections. Cold Spring Harb Perspect Med 2(12):a010272

– Fernandez SJB & Ferrier P (2013) Epigenetic aspects of lymphocyte antigen receptor gene rearrangement of ‘when stochaticity completes randomness’. Immunology 139:141-150
(nb that the final essay will deal in detail with somatic recombination of B and T cell receptor genes)

– Kondilis-Mangum HD & Wade PA (2012) Epigenetics and the adaptive response. Mol Aspects of Med, http://dx.doi.org/10.1016/j.mam.2012.06.008 (EPub ahead of print)

– Liston A, Linterman M & Lu L-F (2010) MicorRNA in the adaptive immune system, in sickness ans in health. J Clin Immunol 30:339-346
Henry Stewart talks:
– The silent revolution: An introduction to gene regulation by microRNAs (2007). Dr Frank Slack 39 min
– DNA methylathion (2007). Prof Adrian Bird 43 min
– Epigenetic control by histone methylation (2007). Dr Thomas Jenuwein 68 min
– MicroRNA biogenesis (2007). Dr Narry Kim 31 min
– Epigenomics of complex disease (2011). Prof Art Petronis 29 min
– Asthma: an epidemic caused by epigenetics (2011). Prof David Schwartz 35 min