Title:Epigenetic influence on immunity
Work:Describe epigenetic mechanisms involved in the regulation of gene expression with reference to their influence in the immune system
Instructions:
You should use tables and diagrams as appropriate. Your assignment must be fully referenced and include a bibliography. Max 1500 words (not including references) – please include the word count for your assignment on the first page. Include your student ID in the header of each page. Each page should be numbered as pg X of Y.
Suggested resources:
– Hirst M & Marra MA (2009) Epigenetics and human disease. Int J Biochem & Cell Biol 41:136-146
– Backdahl L, Bushell, A & Beck S (2009) Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int J Biochem & Cell Biol 41:176-184
– Editorial (March 2013) The dynamic epigenome. Nature Structural and Molecular Biology. 20:258 (Focus issue)
– Teperino R, Lempradl A & Pospisilik JA (2013) Bridging epigenomics and complex disease: the basics. Cell Mol Life Sci 70:1609-1621
– Mercer TR & Mattick JS (2013) Structure and function of long non-coding RNAs in epigenetic regulation. Nat Struct and Mol Biol. 20:300-306
– Kanno Y et al (2012) Transcriptional and epigenetic control of T helper cell specification: Molecular mechanisms underlying commitment and plasticity. Ann Rev Immunol 30:707-731
– Wilson CB, Rowell E & Sekimata M (2009) Epigenetic control of T-helper-cell differentiation. Nat Rev Immunology 9:91-104
– Naito T & Taniuchi (2013) Roles of repressive epigenetic machinery in lineage decision of T cells. Immunology 139:151-157
– Ohkura N, Kitagawa Y & Sakaguchi S (2013) Development and maintenance of regulatory T cells. Immunity 38:414-423
– Richardson B (2007) Primer: epigenetics of autoimmunity. Nature Clinical Practice RHEUMATOLOGY 3: 521-527
– Brooks WH et al (2010) Epigenetics and autoimmunity. J Autoimmunity 34:J207-J219
-Bierne H, Hampn M and Cossart P (2012) Epigenetics and bacterial infections. Cold Spring Harb Perspect Med 2(12):a010272
– Fernandez SJB & Ferrier P (2013) Epigenetic aspects of lymphocyte antigen receptor gene rearrangement of ‘when stochaticity completes randomness’. Immunology 139:141-150
(nb that the final essay will deal in detail with somatic recombination of B and T cell receptor genes)
– Kondilis-Mangum HD & Wade PA (2012) Epigenetics and the adaptive response. Mol Aspects of Med, http://dx.doi.org/10.1016/j.mam.2012.06.008 (EPub ahead of print)
– Liston A, Linterman M & Lu L-F (2010) MicorRNA in the adaptive immune system, in sickness ans in health. J Clin Immunol 30:339-346
Henry Stewart talks:
– The silent revolution: An introduction to gene regulation by microRNAs (2007). Dr Frank Slack 39 min
– DNA methylathion (2007). Prof Adrian Bird 43 min
– Epigenetic control by histone methylation (2007). Dr Thomas Jenuwein 68 min
– MicroRNA biogenesis (2007). Dr Narry Kim 31 min
– Epigenomics of complex disease (2011). Prof Art Petronis 29 min
– Asthma: an epidemic caused by epigenetics (2011). Prof David Schwartz 35 min
